Calendario
| 26/10/2021 | ||
| Preußen Münster | 10:30 am | Hertha Berlin |
| Babelsberg | 10:30 am | RB Leipzig |
| 1860 München | 10:30 am | Schalke 04 |
| TSG 1899 Hoffenheim | 10:30 am | Holstein Kiel |
| Borussia Dortmund | 12:00 pm | Ingolstadt 04 |
| VFL Osnabrück | 12:45 pm | SC Freiburg |
| Nürnberg | 12:45 pm | Hamburg |
| Mainz | 12:45 pm | Arminia Bielefeld |
| 27/10/2021 | ||
| Waldhof Mannheim | 10:30 am | Union Berlin |
| VFL Bochum | 10:30 am | Augsburg 1907 |
| Dynamo Dresden | 10:30 am | FC St. Pauli |
| Bayer 04 Leverkusen | 10:30 am | Karlsruhe |
| Hannover 96 | 12:45 pm | Fortuna Düsseldorf |
| Borussia Mönchengladbach | 12:45 pm | Bayern Munich |
| Jahn Regensburg | 12:45 pm | Hansa Rostock |
| Stuttgart | 12:45 pm | FC Cologne |